COTRIM 50 is a premium veterinary antimicrobial formulation containing Trimethoprim and Sulfadiazine Sodium. This powerful combination provides broad-spectrum antibacterial activity and is widely used for the treatment and control of bacterial infections in poultry, livestock, and companion animals.
The synergistic action of Trimethoprim and Sulfadiazine Sodium interferes with bacterial folic acid synthesis at two sequential stages, resulting in a potent bactericidal effect against susceptible microorganisms. This dual mechanism helps improve treatment efficacy and supports rapid recovery.
Composition
- Trimethoprim…………USP……….80.000mg
- Sulfadiazine Sodium…….USP…….420.00mg
(Product complies Prix specs)
Description
COTRIM 50 combines Trimethoprim and Sulfadiazine Sodium, two antimicrobial agents that work synergistically to provide broad-spectrum antibacterial coverage.
Sulfadiazine Sodium inhibits the formation of dihydrofolic acid, while Trimethoprim blocks the conversion of dihydrofolic acid to tetrahydrofolic acid. By targeting two sequential steps in bacterial folic acid metabolism, the combination produces a highly effective bactericidal action.
This dual-action formulation is effective against a wide range of Gram-positive and Gram-negative bacteria and is commonly used in veterinary medicine for managing severe bacterial infections affecting multiple body systems.
Indications
- Respiratory tract infections
- Gastrointestinal bacterial infections
- Urinary tract infections
- Systemic bacterial infections
- Enteric diseases caused by susceptible bacteria
- Mixed bacterial infections in poultry and livestock
Contra indications
Do not administer to animals known to be hypersensitive to sulfonamides, trimethoprim, or related compounds.
Use according to veterinary recommendations and applicable local regulations.
Side effects
When used according to recommended guidelines, adverse effects are uncommon. Occasional hypersensitivity reactions, digestive disturbances, or reduced feed intake may occur in sensitive animals.
Dosage
For veterinary use only.
Administer according to the dosage instructions provided by a veterinarian or product label.
Calves, sheep and goats
1 gram cotrim 50 wsp per16.5-33 kg body weight (15-30 mg/kg body wieght) for 3 days mixed with milk or milk replacer.
Poultry
Cotrim 50 wsp. 20-33 gm 100 liters of drinking water
(30-50mg/kg body weight) for 3-5 days.
Treatment: 1 gm in 4 liters of drinking water 3-5 days.
Prevention: 1 gm in 5 liters of drinking water 3-5 days.
Withdrawal times
Observe withdrawal periods as specified on the product label and local regulatory requirements.
Packaging
Available in veterinary packaging sizes.
Special Note
- Prepare fresh medicated water daily during treatment.
- Ensure adequate water consumption throughout the treatment period.
- Use under veterinary supervision.
- Complete the full treatment course as recommended for optimal results.
Specifications
| Feature | Details |
|---|---|
| Product Name | COTRIM 50 |
| Active Ingredients | Trimethoprim and Sulfadiazine Sodium |
| Product Type | Veterinary Antimicrobial |
| Drug Class | Trimethoprim-Sulfonamide Combination |
| Primary Action | Broad-Spectrum Bactericidal Activity |
| Mechanism of Action | Sequential Inhibition of Bacterial Folic Acid Synthesis |
| Target Species | Poultry, Livestock, and Companion Animals |
| Indications | Respiratory, Gastrointestinal, Urinary, and Systemic Bacterial Infections |
| Administration | As Directed by a Veterinarian |
| Usage | Veterinary Use Only |
What’s in the Box
- 12 x COTRIM 50 Water Soluble Powder
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